{"id":54916,"date":"2024-04-24T07:00:00","date_gmt":"2024-04-24T05:00:00","guid":{"rendered":"https:\/\/www.ipsen.com\/press-releases\/ipsen-delivers-strong-sales-in-the-first-quarter-of-2024-driven-by-growth-platforms-new-medicines-and-confirms-its-full-year-guidance\/"},"modified":"2024-07-23T11:51:31","modified_gmt":"2024-07-23T09:51:31","slug":"ipsen-delivers-strong-sales-in-the-first-quarter-of-2024-driven-by-growth-platforms-new-medicines-and-confirms-its-full-year-guidance","status":"publish","type":"press_release","link":"https:\/\/www.ipsen.com\/press-releases\/ipsen-delivers-strong-sales-in-the-first-quarter-of-2024-driven-by-growth-platforms-new-medicines-and-confirms-its-full-year-guidance\/","title":{"rendered":"Ipsen delivers strong sales in the first quarter of 2024, driven by growth platforms &amp; new medicines, and confirms its full-year guidance"},"content":{"rendered":"<p><strong>PARIS, FRANCE, 24 April 2024 <\/strong>&#8211; Ipsen (Euronext: IPN; ADR: IPSEY), a global specialty-care biopharmaceutical company, today presents its sales for the first quarter of 2024.<\/p>\n<table style=\"border-collapse: collapse;width:440.25pt;border-collapse:collapse\">\n<tr>\n<td rowspan=\"2\" style=\"width:243px;text-align: center;vertical-align: middle;vertical-align: middle;text-align: center;vertical-align: middle\">\u202f\u00a0<br \/>\u202f\u00a0<\/p>\n<p>\u00a0<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;vertical-align: middle\"><strong>Q1 2024<\/strong>\u202f\u00a0<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;vertical-align: middle\"><strong>Q1 2023<\/strong><strong>\u202f<\/strong>\u00a0<\/td>\n<td colspan=\"2\" style=\"width:172px;text-align: center;vertical-align: middle;vertical-align: middle\"><strong>% change<\/strong>\u202f\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-bottom: solid black 1pt;vertical-align: middle\"><strong>\u20acm<\/strong>\u202f\u00a0<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-bottom: solid black 1pt;vertical-align: middle\"><strong>\u20acm<\/strong>\u202f\u00a0<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-bottom: solid black 1pt;vertical-align: middle\"><strong>Actual<\/strong><\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-bottom: solid black 1pt;vertical-align: middle\"><strong>CER<\/strong><sup><strong>1<\/strong><\/sup><\/td>\n<\/tr>\n<tr>\n<td style=\"width:243px;text-align: center;vertical-align: middle;border-top: solid black 1pt;vertical-align: middle\">Growth platforms<sup>2<\/sup><\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-top: solid black 1pt;vertical-align: middle\">509.7<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-top: solid black 1pt;vertical-align: middle\">452.0<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-top: solid black 1pt;vertical-align: middle\">12.8%<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-top: solid black 1pt;vertical-align: middle\">16.2%<\/td>\n<\/tr>\n<tr>\n<td style=\"width:243px;text-align: center;vertical-align: middle;vertical-align: middle\">New medicines<sup>3<\/sup><\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;vertical-align: middle\">45.5<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;vertical-align: middle\">14.3<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;vertical-align: middle\">n\/a<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;vertical-align: middle\">n\/a<\/td>\n<\/tr>\n<tr>\n<td style=\"width:243px;text-align: center;vertical-align: middle;vertical-align: middle\">Somatuline<sup>\u00ae<\/sup><\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;vertical-align: middle\">257.8<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;vertical-align: middle\">263.2<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;vertical-align: middle\">-2.0%<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;vertical-align: middle\">-1.3%<\/td>\n<\/tr>\n<tr>\n<td style=\"width:243px;text-align: center;vertical-align: middle;border-bottom: solid black 1pt;vertical-align: middle\">Other<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-bottom: solid black 1pt;vertical-align: middle\">9.5<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-bottom: solid black 1pt;vertical-align: middle\">12.4<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-bottom: solid black 1pt;vertical-align: middle\">-23.8%<\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-bottom: solid black 1pt;vertical-align: middle\">-20.5%<\/td>\n<\/tr>\n<tr>\n<td style=\"width:243px;text-align: center;vertical-align: middle;border-top: solid black 1pt;vertical-align: middle\"><strong>Total Sales<\/strong><\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-top: solid black 1pt;vertical-align: middle\"><strong>822.4<\/strong><\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-top: solid black 1pt;vertical-align: middle\"><strong>741.9<\/strong><\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-top: solid black 1pt;vertical-align: middle\"><strong>10.9%<\/strong><\/td>\n<td style=\"width:86px;text-align: center;vertical-align: middle;border-top: solid black 1pt;vertical-align: middle\"><strong>13.3%<\/strong><\/td>\n<\/tr>\n<\/table>\n<p align=\"justify\"><strong>Highlights <\/strong><\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">Total-sales growth of 13.3% at CER<sup><strong><em>1<\/em><\/strong><\/sup>, or 10.9% as reported, driven by the 16.2%<sup><strong><em>1<\/em><\/strong><\/sup> increase in sales of the growth platforms<sup><strong><em>2<\/em><\/strong><\/sup> and the increased contributions from new medicines, while Somatuline sales declined by only 1.3%<sup><strong><em>1<\/em><\/strong><\/sup><\/li>\n<\/ul>\n<ul type=\"disc\">\n<li style=\"margin-top:6pt;text-align:justify\">Regulatory approval and launch of Onivyde in the U.S. as a first-line treatment for metastatic pancreatic ductal adenocarcinoma (mPDAC) <\/li>\n<li style=\"margin-top:6pt;text-align:justify\">Confirmation of financial guidance for 2024 <\/li>\n<\/ul>\n<p align=\"justify\">\u201cAn excellent first-quarter performance has laid a solid foundation for Ipsen&#8217;s growth in 2024\u201d, commented David Loew, Chief Executive Officer, Ipsen. \u201cThe delivery of our strategic plan continues to be evidenced by a strong top line, supported by the success of the growth platforms and the increased contribution of the new medicines. Moreover, the pipeline continues to deliver, illustrated this quarter by the regulatory approval in the U.S. of Onivyde as a first-line treatment for pancreatic cancer.<\/p>\n<p align=\"justify\">\u201cThis year marks a pivotal period for our growth plans, with the launches of four new medicines or indications. Our focus remains on the performance of our portfolio and the expansion of our pipeline, and a well-defined strategy for sustainable growth centred on enhancing the lives and medical outcomes of patients.\u201d<\/p>\n<p><strong>Full-year 2024 guidance<\/strong><\/p>\n<p align=\"justify\">Ipsen has confirmed its financial guidance for 2024, which excludes the impact of any potential additional late-stage<sup>4<\/sup> external-innovation opportunities:<\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">Total-sales growth greater than 6.0%, at constant currency. Based on the average level of exchange rates in March 2024, an adverse\u00a0impact on total sales of around 1% from currencies is expected\n<\/li>\n<li style=\"text-align:justify\">Core operating margin around 30% of total sales, which includes additional R&amp;D expenses from anticipated early and mid-stage external-innovation opportunities\n<\/li>\n<\/ul>\n<p align=\"justify\">Guidance on total sales incorporates expectations for Somatuline of further generic-lanreotide products in the U.S and E.U. <\/p>\n<p align=\"justify\"><strong>Business update<\/strong><\/p>\n<p align=\"justify\">In February 2024, Ipsen announced that the U.S. Food and Drug Administration (FDA) had approved the supplemental new drug application for Onivyde plus oxaliplatin, fluorouracil and leucovorin (NALIRIFOX) as a first-line treatment for adults living with mPDAC. This was the second approval for an Onivyde regimen in mPDAC, after the FDA\u2019s approval in 2015 of Onivyde plus fluorouracil and leucovorin, following disease progression with gemcitabine-based therapy. In conjunction with the approval in the U.S. of Onivyde as a first-line treatment in adults living with mPDAC, Orphan Drug Exclusivity was awarded and regulatory exclusivity was extended to 2031, driven by the automatic seven-year exclusivity period upon approval. <\/p>\n<p align=\"justify\">In April 2024, Ipsen announced an exclusive global licensing agreement for STRO-003, an antibody-drug conjugate (ADC) targeting the ROR1 tumor antigen. STRO-003 is in the final stages of pre-clinical development. The agreement gives Ipsen exclusive worldwide rights to develop and commercialize STRO-003 and is the first ADC candidate to join Ipsen\u2019s expanding pipeline.<\/p>\n<p align=\"justify\">Ipsen and Skyhawk Therapeutics announced, in April 2024, the signing of an exclusive worldwide collaboration to discover and develop novel small molecules that modulate RNA for rare neurological diseases. The agreement includes an option pursuant to which Ipsen would acquire an exclusive licence for the worldwide rights to develop successful development candidates.<\/p>\n<p align=\"justify\"><strong>Onivyde litigation <\/strong><\/p>\n<p align=\"justify\">In March 2024, Ipsen received a Paragraph IV notice letter regarding a 505(b)(2) submission to the U.S. FDA by Conjupro Biotherapeutics, Inc. (Conjupro), requesting approval to market an irinotecan hydrochloride liposome injection for the treatment of patients with mPDAC, following gemcitabine-based therapy. The letter challenges various patents that protect Onivyde and its use. In response, Ipsen filed in April 2024 a patent infringement lawsuit against Conjupro and certain related corporate entities in the U.S. District Court for the District of New Jersey and will fully defend its rights as its patent portfolio includes U.S. patent protection for the liposome composition to expire in 2027, with additional patents covering the formulation and approved use in the treatment of patients with mPDAC following gemcitabine-based therapy having expiration dates up to 2033, with additional protection on the first-line use until 2036.<\/p>\n<p align=\"justify\"><strong>Conference call<\/strong><\/p>\n<p align=\"justify\">A conference call and webcast for investors and analysts will begin today at 1pm CET. Participants can access the call and its details by registering <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=vsfVawNQBi-j-riFHmyT60Lzykee-drH95sz1frjdjNdd6UPoFo9n7mbWLWEdQz47caGS_aBCCREuEZunQTVer7YroppuqZ6OQM5DaZMkzU2LR-E4Z4yDzzJ4zT1VUjO8lo_uNYhtE31LWzm7cQ4wQ==\" rel=\"nofollow noopener\" target=\"_blank\" title=\"here\">here<\/a>; webcast details can be found <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=vsfVawNQBi-j-riFHmyT6ySmdURIszkvoJTTDDaipn9FbMOkicupSViZe_nTS3GuwZHcRSwnr_w7frzK7VpWh1ysg34H7_KwMW6pOSvIOEk=\" rel=\"nofollow noopener\" target=\"_blank\" title=\"here\">here<\/a>. <\/p>\n<p align=\"justify\"><strong>Calendar<\/strong><\/p>\n<p align=\"justify\">Ipsen intends to publish its half-year and second-quarter results on 25 July 2024. <\/p>\n<p align=\"justify\"><strong>Notes<\/strong><\/p>\n<p align=\"justify\">All financial figures are in \u20ac\u00a0millions (\u20acm). The performance shown in this announcement covers the three-month period to 31\u00a0March 2024 (Q1 2024, the quarter), compared to the three-month period to 31\u00a0March 2023 (Q1\u00a02023). <\/p>\n<p align=\"justify\"><strong>About Ipsen <\/strong><\/p>\n<p align=\"justify\">We are a global biopharmaceutical company with a focus on bringing transformative medicines to patients in three therapeutic areas: Oncology, Rare Disease and Neuroscience. Our pipeline is fuelled by external innovation and supported by nearly 100 years of development experience and global hubs in the U.S., France and the U.K. Our teams in more than 40 countries and our partnerships around the world enable us to bring medicines to patients in more than 100 countries.<\/p>\n<p align=\"justify\">Ipsen is listed in Paris (Euronext: IPN) and in the U.S. through a Sponsored Level I American Depositary Receipt program (ADR: IPSEY). For more information, visit\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=JH6WNf4Y473Yd3h0gtjoscnT1deeOb4UDzwBFgV4L6RCCn3cxVYcbPPnfMRmsTzXjGKzbFo13Z_D2iOKUgBi1A==\" rel=\"nofollow noopener\" target=\"_blank\" title=\"\"><u>ipsen.com<\/u><\/a>.<\/p>\n<p align=\"justify\"><strong>Ipsen contacts <\/strong><\/p>\n<p align=\"justify\"><strong>Investors<\/strong><\/p>\n<ul type=\"disc\">\n<li style=\"margin-bottom:6pt;text-align:justify\">Craig Marks\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0+44 (0)7584 349 193 <\/li>\n<li style=\"margin-bottom:6pt;text-align:justify\">Nicolas Bogler\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0+33 6 52 19 98 92<\/li>\n<\/ul>\n<p align=\"justify\"><strong>Media<\/strong><\/p>\n<ul type=\"disc\">\n<li style=\"margin-bottom:6pt;text-align:justify\">Amy Wolf\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0+41 79 576 07 23<\/li>\n<li style=\"margin-bottom:6pt;text-align:justify\">Ioana Piscociu\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0+33 6 69 09 12 96<\/li>\n<\/ul>\n<p align=\"justify\"><strong>Disclaimers and\/or forward-looking statements<\/strong><\/p>\n<p align=\"justify\">The forward-looking statements, objectives and targets contained herein are based on Ipsen\u2019s management strategy, current views and assumptions. Such statements involve known and unknown risks and uncertainties that may cause actual results, performance or events to differ materially from those anticipated herein. All of the above risks could affect Ipsen\u2019s future ability to achieve its financial targets, which were set assuming reasonable macroeconomic conditions based on the information available today. Use of the words \u2018believes\u2019, \u2018anticipates\u2019 and \u2018expects\u2019 and similar expressions are intended to identify forward-looking statements, including Ipsen\u2019s expectations regarding future events, including regulatory filings and determinations. Moreover, the targets described in this document were prepared without taking into account external-growth assumptions and potential future acquisitions, which may alter these parameters. These objectives are based on data and assumptions regarded as reasonable by Ipsen. These targets depend on conditions or facts likely to happen in the future, and not exclusively on historical data. Actual results may depart significantly from these targets given the occurrence of certain risks and uncertainties, notably the fact that a promising medicine in early development phase or clinical trial may end up never being launched on the market or reaching its commercial targets, notably for regulatory or competition reasons. Ipsen must face or might face competition from generic medicine that might translate into a loss of market share. Furthermore, the research and development process involves several stages each of which involves the substantial risk that Ipsen may fail to achieve its objectives and be forced to abandon its efforts with regards to a medicine in which it has invested significant sums. Therefore, Ipsen cannot be certain that favorable results obtained during preclinical trials will be confirmed subsequently during clinical trials, or that the results of clinical trials will be sufficient to demonstrate the safe and effective nature of the medicine concerned. There can be no guarantees a medicine will receive the necessary regulatory approvals or that the medicine will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Other risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and healthcare legislation; global trends toward healthcare cost containment; technological advances, new medicine and patents attained by competitors; challenges inherent in new-medicine development, including obtaining regulatory approval; Ipsen\u2019s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of Ipsen\u2019s patents and other protections for innovative medicines; and the exposure to litigation, including patent litigation, and\/or regulatory actions. Ipsen also depends on third parties to develop and market some of its medicines which could potentially generate substantial royalties; these partners could behave in such ways which could cause damage to Ipsen\u2019s activities and financial results. Ipsen cannot be certain that its partners will fulfil their obligations. It might be unable to obtain any benefit from those agreements. A default by any of Ipsen\u2019s partners could generate lower revenues than expected. Such situations could have a negative impact on Ipsen\u2019s business, financial position or performance. Ipsen expressly disclaims any obligation or undertaking to update or revise any forward-looking statements, targets or estimates contained in this press release to reflect any change in events, conditions, assumptions or circumstances on which any such statements are based, unless so required by applicable law. Ipsen\u2019s business is subject to the risk factors outlined in its registration documents filed with the French Autorit\u00e9\u00a0des March\u00e9s Financiers. The risks and uncertainties set out are not exhaustive and the reader is advised to refer to Ipsen\u2019s latest Universal Registration Document, available on\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=JH6WNf4Y473Yd3h0gtjosW1U0HB0pEDkkgs9Th658Nc04fV4gp7QZlpaTatuPQz2Ifa5I7i0f8MC_hVIhmR_Hg==\" rel=\"nofollow noopener\" target=\"_blank\" title=\"\"><u>ipsen.com<\/u><\/a>.<\/p>\n<hr \/>\n<p align=\"justify\"><sup>1<\/sup> At constant exchange rates (CER), which exclude any foreign-exchange impact by recalculating the performance for the relevant period by applying the exchange rates used for the prior period.<br \/><sup>2<\/sup> Dysport<sup>\u00ae<\/sup> (abobotulinumtoxinA), Decapeptyl<sup>\u00ae<\/sup> (triptorelin), Cabometyx<sup>\u00ae<\/sup> (cabozantinib) and Onivyde<sup>\u00ae<\/sup> (irinotecan).<br \/><sup>3<\/sup> Bylvay<sup>\u00ae<\/sup> (odevixibat), Tazverik<sup>\u00ae<\/sup> (tazemetostat) and Sohonos<sup>\u00ae<\/sup> (palovarotene).<br \/><sup>4<\/sup> Phase III clinical development or later.<\/p>\n<p><\/p>\n<p \/>\n<p id=\"gnw_attachments_section-header\">\n    <strong>Attachment<\/strong>\n<\/p>\n<ul id=\"gnw_attachments_section-items\">\n<li>\n        <a target=\"_blank\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=NJaJFNTTq8EW-iW8NeOo4XWInia4imu87eKNOW9f83liZR8VF65julFkcn4YqrY3Dsr174uroVuVnT-GvNmpMhvWOSYazI8Oqn2pQz8YeVRrJkSfMXoi4ADNRYSTCt5_byJW6DkLlCULhKu_pr-2DtRwFovzWx2aZ62x_d7Y-XmC2gQKaxaTWn_SW7IVtlTe\" title=\"Ipsen - Q1 2024 - sales announcement\" rel=\"nofollow noopener\">Ipsen &#8211; Q1 2024 &#8211; sales announcement<\/a>\n      <\/li>\n<\/ul>\n<p><img src='https:\/\/ml-eu.globenewswire.com\/media\/ZmZiYThkMzktYzIwNC00YzRhLTgzYmYtYTFlYjIzMDQwNzE3LTEyNjgxMTY=\/tiny\/Ipsen-Pharma.png' \/><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"template":"","categories":[1763,1764,149],"tags":[],"class_list":["post-54916","press_release","type-press_release","status-publish","hentry","category-corporate-pressrelease","category-financial-pressrelease","category-pressrelease","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ipsen delivers strong sales in the first quarter of 2024, driven by growth platforms &amp; new medicines, and confirms its full-year guidance<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ipsen.com\/press-releases\/ipsen-delivers-strong-sales-in-the-first-quarter-of-2024-driven-by-growth-platforms-new-medicines-and-confirms-its-full-year-guidance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ipsen delivers strong sales in the first quarter of 2024, driven by growth platforms &amp; 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