{"id":39581,"date":"2024-06-05T08:00:00","date_gmt":"2024-06-05T06:00:00","guid":{"rendered":"https:\/\/www.ipsen.com\/us\/press-releases\/ipsen-presents-long-term-elafibranor-efficacy-and-itch-related-quality-of-life-data-in-patients-with-primary-biliary-cholangitis-2\/"},"modified":"2024-07-03T08:14:11","modified_gmt":"2024-07-03T06:14:11","slug":"ipsen-presents-long-term-elafibranor-efficacy-and-itch-related-quality-of-life-data-in-patients-with-primary-biliary-cholangitis-2","status":"publish","type":"press_release","link":"https:\/\/www.ipsen.com\/us\/press-releases\/ipsen-presents-long-term-elafibranor-efficacy-and-itch-related-quality-of-life-data-in-patients-with-primary-biliary-cholangitis-2\/","title":{"rendered":"Ipsen presents long-term elafibranor efficacy and itch-related quality of life data in patients with primary biliary cholangitis\u00a0\u00a0\u00a0\u00a0"},"content":{"rendered":"<ul type=\"disc\">\n<li style=\"margin-top: 6pt; text-align: justify;\"><strong><em>New data from the ELATIVE<\/em><\/strong><sup><strong><em>\u00ae<\/em><\/strong><\/sup><strong><em> Phase III trial show 70% of patients treated with elafibranor achieved composite endpoint of slowing disease progression measured by biochemical response after 78-weeks<\/em><\/strong><\/li>\n<li style=\"margin-top: 6pt; text-align: justify;\"><strong><em>Data from the itch domain of the PBC-40 and 5-D Itch questionnaires shows the potential of elafibranor to improve itch-related quality of life in patients with moderate-to-severe pruritus <\/em><\/strong><\/li>\n<li style=\"margin-top: 6pt; text-align: justify;\"><strong><em>Significant unmet need remains for new treatment options in primary biliary cholangitis that control disease progression and debilitating symptoms impacting quality of life<\/em><\/strong><\/li>\n<\/ul>\n<p align=\"justify\"><strong>PARIS, FRANCE, 5 June 2024<\/strong>\u00a0Ipsen (Euronext: IPN; ADR: IPSEY) today announced new late-breaking data at the European Association for the Study of the Liver (EASL) Congress demonstrating the enduring efficacy of elafibranor in managing disease progression after 78 weeks of treatment. In the variable double-blind period of the ELATIVE<sup>\u00ae<\/sup> Phase III trial in primary biliary cholangitis (PBC), the potential for elafibranor to improve itch-related quality of life (QoL) as measured by the itch domain of the PBC-40 and the 5-D Itch questionnaire was also demonstrated. Elafibranor is a novel, potential first-in-class, PPAR agonist. It is currently under review by the U.S. Food and Drug Administration, the European Medicines Agency and the UK Medicines and Healthcare Products Regulatory Authority.<\/p>\n<p align=\"justify\">\u201cThere are a significant proportion of people living with PBC who experience worsening disease and debilitating symptoms despite being on treatment. These long-term data from the Phase III ELATIVE study further demonstrate the potential for elafibranor to provide an effective treatment option for these patients,\u201d said Sandra Silvestri, M.D. Executive Vice President and Chief Medical Officer, Ipsen. \u201cA lack of effective management can lead to advanced forms of the disease where liver transplantation may be the only option. Transplants are not trivial, so we must and can do better to preserve native liver function for people living with PBC.\u201d<\/p>\n<p align=\"justify\">Data presented at EASL for patients who had their week-78 double-blind visit (30 patients receiving elafibranor and 13 patients receiving placebo) demonstrated the efficacy of elafibranor was sustained after 78 weeks of treatment with 70% of patients on elafibranor meeting the composite endpoint of biochemical response versus 0% on placebo. Biochemical response was defined as alkaline phosphatase (ALP) &lt;1.67 x upper limit of normal (ULN), an ALP decrease \u2265 15 percent and total bilirubin (TB) \u2264 ULN. ALP and bilirubin are important predictors of PBC disease progression. Reductions in levels of both can indicate reduced liver injury and improved liver function. ALP normalization for patients on elafibranor was sustained out to week-78 as well as across other important biomarkers of liver injury, including total bilirubin and gamma glutamyl transferase.<sup>1<\/sup><\/p>\n<p align=\"justify\">New patient-reported outcome data from ELATIVE at week 52 were also presented, demonstrating the potential beneficial effect of elafibranor on itch-related quality of life, including sleep and functioning. Treatment with elafibranor led to greater reductions in 5-D Itch score which comprises five domains (degree, duration, dimension, disability and distribution) versus placebo. A clinically meaningful reduction in the itch domain of PBC-40 for elafibranor versus placebo was also observed, with a greater proportion of patients treated with elafibranor experiencing improvement in itch-related quality of life. These include across measures of severity of itching, sleep disturbance and emotional impact of itching, versus placebo. In the 5-D Itch domain of duration, reduced itching was reported by 58% of patients receiving elafibranor at week 52, compared with 27% on placebo. Additionally, 80% of patients receiving elafibranor improved to no sleep disturbance or only occasional delay, compared with 30% on placebo. The improvements in 5-D Itch and PBC-40 Itch emphasize the potential of elafibranor to reduce both the severity of PBC symptoms and their impact on QoL.<sup>2<\/sup><\/p>\n<p align=\"justify\">\u201cWhen you have a patient with PBC, it\u2019s vital to manage disease progression, to prevent or delay liver damage or failure. You also want to provide relief from distressing symptoms because they can have a very detrimental impact on quality of life,\u201d said Dr. Christopher Bowlus, Professor of Gastroenterology and Hepatology, University of California Davis, U.S. \u201cThese new data from ELATIVE provide further evidence that elafibranor has the potential to address the two priority treatment goals by demonstrating longer-term improvements in the prognostic markers of disease progression, as well as potential improvements in pruritus-symptom severity and impacts on the quality of life.\u201d<\/p>\n<p align=\"justify\">PBC is a rare, progressive, autoimmune cholestatic liver disease, in which the body attacks and gradually destroys the liver\u2019s small bile ducts.<sup>3<\/sup> If left untreated, bile and toxins can build up, leading to scarring of the liver and eventual liver failure.<sup>3<\/sup><sup>&#8211;<\/sup><sup>5<\/sup> Symptoms of PBC can have a substantial impact on a person\u2019s QoL, including fatigue and itching.<sup>6<\/sup><sup>,<\/sup><sup>7<\/sup> However, while some people living with PBC may not display symptoms, they remain at risk of disease progression and liver damage, making active disease management vital.<sup>8<\/sup><\/p>\n<p align=\"justify\">Ipsen also presented new data from its growing rare cholestatic liver disease portfolio at EASL, including data on its treatment for progressive familial intrahepatic cholestasis and Alagille syndrome.<\/p>\n<p align=\"center\"><strong>ENDS<\/strong><\/p>\n<p align=\"justify\"><strong>About ELATIVE <\/strong><\/p>\n<p align=\"justify\">ELATIVE is a multi-center, randomized, double-blind, placebo-controlled Phase III clinical trial, with an open-label long-term extension (NCT04526665). ELATIVE is evaluating the efficacy and safety of elafibranor 80mg once daily versus placebo for the treatment of patients with PBC with an inadequate response or intolerance to ursodeoxycholic acid (UDCA), the existing first-line therapy for PBC. The trial enrolled 161 patients who were randomized 2:1 to receive elafibranor 80mg once daily or placebo. Patients with an inadequate response to UDCA would continue to receive UDCA in combination with elafibranor or placebo, while patients unable to tolerate UDCA would receive only elafibranor or placebo. Patients continued their assigned treatment after Week 52 until all patients had completed their treatment or for a maximum of 104 weeks. Data was also collected during this period, and additional analyses were conducted with a focus on Week 78.<\/p>\n<p align=\"justify\"><strong>About Ipsen <\/strong><\/p>\n<p align=\"justify\">We are a global biopharmaceutical company with a focus on bringing transformative medicines to patients in three therapeutic areas: Oncology, Rare Disease and Neuroscience.<\/p>\n<p align=\"justify\">Our pipeline is fueled by external innovation and supported by nearly 100 years of development experience and global hubs in the U.S., France and the U.K. Our teams in more than 40 countries and our partnerships around the world enable us to bring medicines to patients in more than 80 countries.<\/p>\n<p align=\"justify\">Ipsen is listed in Paris (Euronext: IPN) and in the U.S. through a Sponsored Level I American Depositary Receipt program (ADR: IPSEY). For more information, visit ipsen.com.<\/p>\n<p align=\"justify\"><strong>Ipsen contacts <\/strong><\/p>\n<p align=\"justify\"><strong>Investors<\/strong><\/p>\n<ul type=\"disc\">\n<li style=\"margin-bottom: 6pt; text-align: justify;\"><strong>Craig Marks | + 44 7584 349 193<\/strong><\/li>\n<li style=\"margin-bottom: 6pt; text-align: justify;\"><strong>Nicolas Bogler | + 33 6 52 19 98 92<\/strong><\/li>\n<\/ul>\n<p align=\"justify\"><strong>Media<\/strong><\/p>\n<ul type=\"disc\">\n<li style=\"margin-bottom: 6pt; text-align: justify;\"><strong>Amy Wolf | + 41 79 576 07 23 | amy.wolf@ipsen.com<\/strong><\/li>\n<li style=\"margin-bottom: 6pt; text-align: justify;\"><strong>Anna Gibbins | + 44 7717 801900 | anna.gibbins@ipsen.com<\/strong><\/li>\n<\/ul>\n<p align=\"justify\"><strong>Disclaimers and\/or Forward-Looking Statements<\/strong><\/p>\n<p>The forward-looking statements, objectives and targets contained herein are based on Ipsen\u2019s management strategy, current views and assumptions. Such statements involve known and unknown risks and uncertainties that may cause actual results, performance or events to differ materially from those anticipated herein. All of the above risks could affect Ipsen\u2019s future ability to achieve its financial targets, which were set assuming reasonable macroeconomic conditions based on the information available today. Use of the words \u2018believes\u2019, \u2018anticipates\u2019 and \u2018expects\u2019 and similar expressions are intended to identify forward-looking statements, including Ipsen\u2019s expectations regarding future events, including regulatory filings and determinations. Moreover, the targets described in this document were prepared without taking into account external-growth assumptions and potential future acquisitions, which may alter these parameters. These objectives are based on data and assumptions regarded as reasonable by Ipsen. These targets depend on conditions or facts likely to happen in the future, and not exclusively on historical data. Actual results may depart significantly from these targets given the occurrence of certain risks and uncertainties, notably the fact that a promising medicine in early development phase or clinical trial may end up never being launched on the market or reaching its commercial targets, notably for regulatory or competition reasons. Ipsen must face or might face competition from generic medicine that might translate into a loss of market share. Furthermore, the research and development process involves several stages each of which involves the substantial risk that Ipsen may fail to achieve its objectives and be forced to abandon its efforts with regards to a medicine in which it has invested significant sums. Therefore, Ipsen cannot be certain that favorable results obtained during preclinical trials will be confirmed subsequently during clinical trials, or that the results of clinical trials will be sufficient to demonstrate the safe and effective nature of the medicine concerned. There can be no guarantees a medicine will receive the necessary regulatory approvals or that the medicine will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Other risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and healthcare legislation; global trends toward healthcare cost containment; technological advances, new medicine and patents attained by competitors; challenges inherent in new-medicine development, including obtaining regulatory approval; Ipsen\u2019s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of Ipsen\u2019s patents and other protections for innovative medicines; and the exposure to litigation, including patent litigation, and\/or regulatory actions. Ipsen also depends on third parties to develop and market some of its medicines which could potentially generate substantial royalties; these partners could behave in such ways which could cause damage to Ipsen\u2019s activities and financial results. Ipsen cannot be certain that its partners will fulfil their obligations. It might be unable to obtain any benefit from those agreements. A default by any of Ipsen\u2019s partners could generate lower revenues than expected. Such situations could have a negative impact on Ipsen\u2019s business, financial position or performance. Ipsen expressly disclaims any obligation or undertaking to update or revise any forward-looking statements, targets or estimates contained in this press release to reflect any change in events, conditions, assumptions or circumstances on which any such statements are based, unless so required by applicable law. Ipsen\u2019s business is subject to the risk factors outlined in its registration documents filed with the French Autorit\u00e9\u00a0des March\u00e9s Financiers. The risks and uncertainties set out are not exhaustive and the reader is advised to refer to Ipsen\u2019s latest Universal Registration Document, available on\u00a0<a title=\"ipsen.com\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=VrgD4_IVvb9sVhxJQqr1FG0dGvb9enxq_bPrDOJBq3yeO2c-Ib8Y9eJVAQ5E0_e_B7Y4cecLbhi-JHIUSKhtaIJNdFUehbWW6dAmbP41yHOiePwTJyYwUbSMx1Atca0Xg30Djj-Z9ZOsooOhKQtXW7wfbEcKQhhZZMFNkkIsyFuUgUIxUWuRhKuZUkslW_gBuP9ucfMPz_Ql7RJJcsWJ_ucZg2AmUo-qLci9aclt8CU=\" target=\"_blank\" rel=\"nofollow noopener\">ipsen.com<\/a>.<\/p>\n<p align=\"justify\"><strong>References<\/strong><\/p>\n<ol style=\"list-style-type: decimal;\">\n<li style=\"text-align: justify;\">Bowlus et al. J. Hepatol. 2024\u00a0; 80(S1)S80<\/li>\n<li style=\"text-align: justify;\">Kremer et al. J. Hepatol. 2024; 80(S1)S91<\/li>\n<li style=\"text-align: left;\">EASL. J Hepatol. 2017; 67(1):145-172.<\/li>\n<li style=\"text-align: left;\">Younossi ZM, et al. Am J Gastroenterol. 2019; 114(1):48\u201363.<\/li>\n<li style=\"text-align: left;\">Galoosian A, et al. J Clin Transl Hepatol. 2020; 8(1), pp. 49-60.<\/li>\n<li style=\"text-align: left;\">Mells GF, et al. Hepatology. 2013; 58: 273-283.<\/li>\n<li style=\"text-align: left;\">C Levy, et al. Abstract presented at ISPOR, 7-11 May 2023, Boston.<\/li>\n<li style=\"text-align: left;\">Prince MI, et al. Gut. 2004; 53(6), pp.865-870.<\/li>\n<\/ol>\n<p id=\"gnw_attachments_section-header\"><strong>Attachment<\/strong><\/p>\n<ul id=\"gnw_attachments_section-items\">\n<li><a title=\"PR_ELATIVE EASL 2024_05062024\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=RUeaOKknoOYYfNmzIMdlkEwxIIG6LejP6_yNgnyJmc7AR54F3advBlQr0gGqIbcyC5cACSoE759Of_osrydJNHShyhYzvcNgw2nFMZlCVx34ZItLxeAHSv6JZEErQmbFxgDnUzSH71GkXKoeOA6_07JNjr-_2jSVav0Sw5tJTL0gi6CR3bkGQu8xXTgrnJfo\" target=\"_blank\" rel=\"nofollow noopener\">PR_ELATIVE EASL 2024_05062024<\/a><\/li>\n<\/ul>\n<p><img decoding=\"async\" src=\"https:\/\/ml-eu.globenewswire.com\/media\/NTJmN2E4ODItM2VlOS00NzdkLWJlNDYtNjQyZmZlNmU1MGY4LTEyNjgxMTY=\/tiny\/Ipsen-Pharma.png\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"template":"","categories":[556,535],"tags":[],"class_list":["post-39581","press_release","type-press_release","status-publish","hentry","category-corporate-pressrelease","category-rare-diseases-pressrelease","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - 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