Ipsen to Highlight Expanded Oncology Portfolio and Advances in Follicular Lymphoma Research at ASH 2022

• New investigational tazemetostat combination data in relapsed/refractory follicular lymphoma selected for oral presentation at ASH 2022
• An established leader in difficult-to-treat cancer types expands oncology focus into hematology with acquisition of Epizyme

November 3, 2022 – Ipsen (Euronext: IPN; ADR: IPSEY) will highlight its expanded portfolio in hematology at the American Society of Hematology (ASH) Annual Meeting from December 10-13 following its recent acquisition of Epizyme. The company will share an oral presentation on new interim data from a Phase 1b/3 trial of investigational tazemetostat, an oral EZH2 inhibitor, as a second-line combination regimen for relapsed/refractory follicular lymphoma (FL).

“As a company, we have long pursued solutions for some of the most difficult-to-treat cancer types, including pancreatic cancer and neuroendocrine tumors. Our recent portfolio expansion further delivers on our promise and also builds our scientific expertise in epigenetics,” said Mónica de Abadal, Senior Vice President of North America Medical Affairs at Ipsen. “We’re excited to showcase early results from the ongoing combination data in relapsed/refractory follicular lymphoma at ASH.”

New interim results from SYMPHONY-1 combination study
In an oral presentation at ASH, new interim data from the safety run-in of the Phase 1b/3 SYMPHONY-1 study will be presented, including response data, duration of response, and progression-free survival data, as well as safety data. The SYMPHONY-1 trial is an international, multicenter, randomized, double-blind, active-controlled, three-stage study evaluating the safety and efficacy of investigational tazemetostat in combination with lenalidomide and rituximab for second-line treatment of relapsed/refractory FL.

Monday, December 12 at 5:45 p.m. ET (R06-R09) Session #623: Tazemetostat in Combination with Lenalidomide and Rituximab in Patients with Relapsed/Refractory Lymphoma: Phase 1b/3 Results of SYMPHONY-1

Follicular lymphoma is a cancer of the lymphatic system and a type of non-Hodgkin lymphoma (NHL) that develops when the body makes abnormal B lymphocytes. These lymphocytes are a type of white blood cell that normally helps fight infections. In FL, the lymphocytes slowly build up in the lymph nodes or other body organs. Each year, approximately 20,000 people in the U.S. are diagnosed with FL and most are diagnosed with advanced disease, as it can be difficult to detect.

Epigenetics, an emerging frontier in cancer treatment

The acquisition of Epizyme includes an epigenetic platform, which is an innovative approach to developing investigational cancer medicines that focuses on identifying and targeting key targets that alter or dysregulate the basic structural components of chromosomes in DNA–called chromatin–to slow or stop tumor cell proliferation.

ENDS

About Ipsen 

Ipsen is a global, mid-sized biopharmaceutical company focused on transformative medicines in Oncology, Rare Disease and Neuroscience. With Specialty Care sales of €2.6bn in FY 2021, Ipsen sells medicines in over 100 countries. Alongside its external-innovation strategy, the Company’s research and development efforts are focused on its innovative and differentiated technological platforms located in the heart of leading biotechnological and life-science hubs: Paris-Saclay, France; Oxford, U.K.; Cambridge, U.S.; Shanghai, China. Ipsen, excluding its Consumer HealthCare business, has around 4,500 colleagues worldwide and is listed in Paris (Euronext: IPN) and in the U.S. through a Sponsored Level I American Depositary Receipt program (ADR: IPSEY). For more information, visit ipsen.com

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