{"id":41312,"date":"2023-10-31T10:44:59","date_gmt":"2023-10-31T08:44:59","guid":{"rendered":"https:\/\/www.ipsen.com\/?p=41312"},"modified":"2023-11-30T07:47:30","modified_gmt":"2023-11-30T05:47:30","slug":"innover-pour-les-personnes-vivant-avec-une-cholangite-biliaire-primitive","status":"publish","type":"post","link":"https:\/\/www.ipsen.com\/fr\/rare-diseases-fr\/innover-pour-les-personnes-vivant-avec-une-cholangite-biliaire-primitive\/","title":{"rendered":"Innover pour les personnes vivant avec une cholangite biliaire primitive"},"content":{"rendered":"\n<p>Chez Ipsen, nous nous concentrons depuis de nombreuses ann\u00e9es sur le d\u00e9veloppement de traitements nouveaux et innovants pour les maladies rares en endocrinologie, dans les maladies osseuses rares et plus r\u00e9cemment dans les maladies h\u00e9patiques rares. Cette orientation continue d\u2019\u00eatre un \u00e9l\u00e9ment essentiel de notre strat\u00e9gie de croissance.\u00a0<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ipsen.com\/leadership\/sandra-silvestri-md-phd\/\">Sandra Silvestri, Directrice M\u00e9dicale d&rsquo;Ipsen<\/a>, partage ici ses r\u00e9flexions sur les d\u00e9fis et les avantages de l&rsquo;innovation pour la maladie h\u00e9patique cholestatique rare, auto-immune, la cholangite biliaire primitive ou CBP.<\/p>\n\n\n    <section class=\"video-card \">\n        <div class=\"container\">\n            <!-- Block Details -->\n            <div class=\"video-card-header\">\n                <h2 class=\"video-card-block-title hidden\"><\/h2>\n                <p class=\"charcoal-grey video-card-block-summary hidden\"> <\/p>\n            <\/div>\n\n            <!-- Video Iframe embed -->\n                            <div class=\"video-embed\"> \n                <iframe loading=\"lazy\" title=\"Comms_PBC_AASLD Thought Leadership Sanda Silvestri full video_Oct 2023\" src=\"https:\/\/player.vimeo.com\/video\/879705195?app_id=122963&#038;autoplay=1&#038;muted=1&#038;controls=1&#038;loop=1&#038;autopause=1&#038;background=0\" width=\"640\" height=\"360\" frameborder=\"0\" allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media\" frameborder=\"0\" allow=\"autoplay; fullscreen; picture-in-picture\" data-ot-ignore><\/iframe>                <\/div>\n            \n            <!-- Block CTA -->\n            <div class=\"cta-block hidden\">\n                            <\/div>\n\n        <\/div>\n    <\/section>\n\n\n\n<p>La CBP est une maladie qui affecte principalement les femmes, avec neuf femmes diagnostiqu\u00e9es pour un homme.<sup>1 <\/sup>Elle provoque une inflammation chronique des voies biliaires et, si elle n&rsquo;est pas trait\u00e9e, peut entra\u00eener une accumulation de bile et de toxines (cholestase) dans le foie, provoquant inflammation chronique et cicatrisation du foie (cirrhose).<sup>1,2,3<\/sup>\u00a0<\/p>\n\n\n\n<p>La CBP est une maladie qui dure toute la vie et qui peut s&rsquo;aggraver avec le temps.<sup>4<\/sup> Si elle n&rsquo;est pas prise en charge efficacement, la CBP peut entra\u00eener des l\u00e9sions h\u00e9patiques progressives et la n\u00e9cessit\u00e9 d&rsquo;une greffe du foie.<sup>1,2<\/sup> De plus, la vie quotidienne des patients est affect\u00e9e par des sympt\u00f4mes d\u00e9bilitants, notamment la fatigue et des d\u00e9mangeaisons s\u00e9v\u00e8res (prurit).<sup>5,6<\/sup> <\/p>\n\n\n\n<p>Un patient atteint de CBP nous a dit : \u00ab Vivre avec une CBP peut \u00eatre tr\u00e8s difficile pour de nombreuses personnes. La peur de la progression de la maladie plane sur vous et vous devez g\u00e9rer du mieux que vous pouvez le fardeau des sympt\u00f4mes quotidiens, des sympt\u00f4mes qui peuvent parfois \u00eatre si d\u00e9bilitants qu\u2019il faut toute sa force pour passer une autre journ\u00e9e.\u00a0<\/p>\n\n\n\n<p>Jusqu&rsquo;\u00e0 40 % des personnes atteintes de CBP ne r\u00e9pondent pas au traitement de premi\u00e8re intention.<sup>7<\/sup> Si les patients ne r\u00e9pondent pas ou sont intol\u00e9rants, le seul traitement de deuxi\u00e8me intention approuv\u00e9 disponible provoque g\u00e9n\u00e9ralement un prurit ou des d\u00e9mangeaisons s\u00e9v\u00e8res comme effet secondaire, exacerbant la situation et des sympt\u00f4mes d\u00e9j\u00e0 d\u00e9bilitants.<sup>8<\/sup> <\/p>\n\n\n\n<p>Comme Sandra le d\u00e9clare dans cette vid\u00e9o, nous devons innover pour trouver de nouveaux traitements efficaces pour des maladies comme la CBP, qui ont des cons\u00e9quences \u00e9normes sur la vie des personnes atteintes. Sans innovation, nous restons immobiles. Apr\u00e8s pr\u00e8s d\u2019une d\u00e9cennie sans nouveaux d\u00e9veloppements, nous assistons d\u00e9sormais \u00e0 une croissance dans les innovations m\u00e9dicales. Cela ne peut \u00eatre que b\u00e9n\u00e9fique pour les patients atteints de CBP, qui ont d\u00e9sesp\u00e9r\u00e9ment besoin de m\u00e9dicaments efficaces et bien tol\u00e9r\u00e9s pour g\u00e9rer la maladie avec laquelle ils vivent.<\/p>\n\n\n\n<!--Alert Card Layout Start Here-->\n<section class=\"alertcard-section\">\n      <div class=\"container\">\n        <!--Alert Box HTML Start Here-->\n        <div class=\"alert-box general-box\">\n                  <div class=\"info-contents\">\n            <p class=\"info-head visible\">R\u00e9f\u00e9rences<\/p>\n            <p class=\"info-sub-head-para hidden\"><\/p>\n            <div class=\"alert-content visible\"><ol>\n<li><em>Galoosian A, et al. 2020. Clinical updates in primary biliary cholangitis: trends, epidemiology, diagnostics, and new therapeutic approaches.\u00a0J Clin Transl Hepatol.\u00a08(1), pp. 49-60.<\/em><\/li>\n<li><em>Younossi ZM, et al. 2019. Diagnosis and Management of Primary Biliary Cholangitis. Am J Gastroenterol. 114(1):48\u201363.<\/em><\/li>\n<li><em>European Association for the Study of the Liver. 2017. EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis. J Hepatol. 67(1):145-172.<\/em><\/li>\n<li><em>Hirschfield GM, et al. 2018. The British Society of Gastroenterology\/UK-PBC primary biliary cholangitis treatment and management guidelines. Gut. 67:1568-1594.<\/em><\/li>\n<li><em>Mells GF, et al. 2013. Impact of Primary Biliary Cholangitis on Perceived Quality of Life: The UK-PBC National Study. Hepatology. 58: 273-283.<\/em><\/li>\n<li><em>C Levy, et al. 2023. Understanding the Experience of Patients with Primary Biliary Cholangitis and Pruritus. Abstract presented at ISPOR, 7-11 May 2023, Boston.<\/em><\/li>\n<li><em>Ali AH, Byrne TJ, Lindor KD. 2015. Orphan drugs in development for primary biliary cirrhosis: challenges and progress. Orphan Drugs: Research and Reviews. 5(1), pp..83-97.<\/em><\/li>\n<li><em>Aguilar MT and Chascsa DM. 2020. Update on emerging treatment options for primary biliary cholangitis.\u00a0Hepat Med. Pp.69-77.<\/em><\/li>\n<\/ol>\n<\/div>\n          <\/div>\n        <\/div>\n        <!--Alert Box HTML Start Here-->\n      <\/div>\n    <\/section>\n<!--Alert Card Layout End Here-->\n","protected":false},"excerpt":{"rendered":"<p>Chez Ipsen, nous nous concentrons depuis de nombreuses ann\u00e9es sur le d\u00e9veloppement de traitements nouveaux et innovants pour les maladies<\/p>\n","protected":false},"author":11,"featured_media":20900,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1192],"tags":[],"class_list":["post-41312","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rare-diseases-fr","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Innover pour les personnes vivant avec une cholangite biliaire primitive - Global<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ipsen.com\/fr\/rare-diseases-fr\/innover-pour-les-personnes-vivant-avec-une-cholangite-biliaire-primitive\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Innover pour les personnes vivant avec une cholangite biliaire primitive - 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