A study of the safety, tolerability and effectiveness of EZM0414 investigative product in participants with Relapsed/refractory Multiple Myeloma and Relapsed/refractory Diffuse Large B Cell Lymphoma
This study will include participants with relapsed/refractory (R/R) Multiple Myeloma (MM). MM is a type of cancer of the blood. This study will also include participants with relapsed/refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL). DLBCL is also a type of cancer of the blood. They are referred to as ‘relapsed’ when the disease has come back after treatment and ‘refractory’ when treatment no longer works. The study has 2 main parts, called phase 1 and phase 1b. The main objective of both parts will be to evaluate the safety and tolerability of the study drug, called EZM0414. The main objective of phase 1b will also be to determine the effectiveness of EZM0414. During phase 1 six dose levels will be tested. Participants will receive study drug at the assigned dose level every 28 days. During phase 1b participants will receive study drug at the maximum tolerated dose in 28-day cycles.
A study of the safety, tolerability and effectiveness of EZM0414 investigative product in participants with Relapsed/refractory Multiple Myeloma and Relapsed/refractory Diffuse Large B Cell Lymphoma
This study will include participants with relapsed/refractory (R/R) Multiple Myeloma (MM). MM is a type of cancer of the blood. This study will also include participants with relapsed/refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL). DLBCL is also a type of cancer of the blood. They are referred to as ‘relapsed’ when the disease has come back after treatment and ‘refractory’ when treatment no longer works. The study has 2 main parts, called phase 1 and phase 1b. The main objective of both parts will be to evaluate the safety and tolerability of the study drug, called EZM0414. The main objective of phase 1b will also be to determine the effectiveness of EZM0414. During phase 1 six dose levels will be tested. Participants will receive study drug at the assigned dose level every 28 days. During phase 1b participants will receive study drug at the maximum tolerated dose in 28-day cycles.
En rapport Clinical Trials
![A study to evaluate the effect of phenytoin or itraconazole on the circulating levels of IPN60130 in healthy adult participants A study to evaluate the effect of phenytoin or itraconazole on the circulating levels of IPN60130 in healthy adult participants](https://www.ipsen.com/wp-content/themes/ipsen-main/dist/images/defaultImg.png)
A study to evaluate the effect of phenytoin or itraconazole on the circulating levels of IPN60130 in healthy adult participants
![A Rollover Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged ?14 Years With Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed the Relevant Parent Studies. A Rollover Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged ?14 Years With Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed the Relevant Parent Studies.](https://www.ipsen.com/wp-content/themes/ipsen-main/dist/images/defaultImg.png)
A Rollover Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged ?14 Years With Fibrodysplasia Ossificans Progressiva...
![A study to assess whether adding maintenance cabozantinib (XL184) to best supportive care helps children, adolescents and young adults with osteosarcoma. A study to assess whether adding maintenance cabozantinib (XL184) to best supportive care helps children, adolescents and young adults with osteosarcoma.](https://www.ipsen.com/wp-content/themes/ipsen-main/dist/images/defaultImg.png)
A study to assess whether adding maintenance cabozantinib (XL184) to best supportive care helps children, adolescents and young adults with osteosarcoma.
![A study to evaluate the effectiveness and safety of Dysport® for the prevention of episodic migraine in adults A study to evaluate the effectiveness and safety of Dysport® for the prevention of episodic migraine in adults](https://www.ipsen.com/wp-content/themes/ipsen-main/dist/images/defaultImg.png)
A study to evaluate the effectiveness and safety of Dysport® for the prevention of episodic migraine in adults
![A study to evaluate the effectiveness and safety of Dysport® for the prevention of chronic migraine in adults A study to evaluate the effectiveness and safety of Dysport® for the prevention of chronic migraine in adults](https://www.ipsen.com/wp-content/themes/ipsen-main/dist/images/defaultImg.png)
A study to evaluate the effectiveness and safety of Dysport® for the prevention of chronic migraine in adults
![A Study to Compare the Safety and Efficacy of Dysport® and Botox® in Adults With Upper Limb Spasticity. A Study to Compare the Safety and Efficacy of Dysport® and Botox® in Adults With Upper Limb Spasticity.](https://www.ipsen.com/wp-content/themes/ipsen-main/dist/images/defaultImg.png)
A Study to Compare the Safety and Efficacy of Dysport® and Botox® in Adults With Upper Limb Spasticity.
![A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours](https://www.ipsen.com/wp-content/themes/ipsen-main/dist/images/defaultImg.png)
A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours
![Efficacy and Safety of Lanreotide Autogel/ Depot 120 mg vs. Placebo in Subjects With Lung Neuroendocrine Tumours Efficacy and Safety of Lanreotide Autogel/ Depot 120 mg vs. Placebo in Subjects With Lung Neuroendocrine Tumours](https://www.ipsen.com/wp-content/themes/ipsen-main/dist/images/defaultImg.png)
Efficacy and Safety of Lanreotide Autogel/ Depot 120 mg vs. Placebo in Subjects With Lung Neuroendocrine Tumours
![Long Term Safety And Effectiveness Of Dysport® In Adults With Cervical Dystonia Long Term Safety And Effectiveness Of Dysport® In Adults With Cervical Dystonia](https://www.ipsen.com/wp-content/themes/ipsen-main/dist/images/defaultImg.png)
Long Term Safety And Effectiveness Of Dysport® In Adults With Cervical Dystonia
![Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia. Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia.](https://www.ipsen.com/wp-content/themes/ipsen-main/dist/images/defaultImg.png)